ABC-101

Mucosal Cancers

ABC-101 demonstrates superior efficacy in preclinical colorectal cancer models compared to standard of care.

Targeting CEA

  • CEA A KEY TUMOR-SPECIFIC ANTIGEN PREVALENT IN GASTROINTESTINAL CANCERS
    CEA a key tumor-specific antigen prevalent in gastrointestinal cancers
  • EXPRESSED IN >98% METASTATIC COLORECTAL CANCER
    Widespread systemic distribution of conventional biologics leads to significant off-target effects and burdensome adverse events for patients.

1.9M

New Cases /Year Worldwide

50%

of patients will have a metastatic form

1st priority MSS KRASmut

80 000 new cases /year US + EU
In 3rd line for all patients’ refractory or relapsing in combination to irinotecan

Targeted Mucosal Action

Superior penetration in mucosal tissues with selective CEA recognition

Immune Recruitment

Engage monocytes, macrophages and granulocytes via CD89 receptor and T reg via FCLR3 receptor.

Tumor Elimination

Induce tumor growth inhibition & apoptosis

Versatile Application In Mucosal Tumors

  • CEA overexpressed in numerous and diverse mucosal cancers.
  • Planned clinical Phase I/II will include 70% of patients suffering from metastatic colorectal cancer and 30% of patients among: advanced gastric cancer, metastatic ovarian cancer, advanced endometriosis cancer, metastatic castration-resistant prostate cancer, metastatic pancreatic ductal adenocarcinoma.

Abcely is shaping a pipeline designed to unlock new therapeutic and market opportunities.

The announcement of a cancer diagnosis is a tsunami that stops a life in its tracks, leaving indelible scars and even shattering it completely. Treatment offers repair and reconstruction, healing the body and restoring its integrity. Treatment through remission and healing gives a second chance at life, which takes on an enhanced, unprecedented and new value that every patient feels after being so afraid of losing it.

The ABCELY logo was inspired by the Japanese tradition of ceramic repair, which, instead of hiding fractures and scars, sublimates them by highlighting them in gold, creating a work of art of immense value while restoring its original functionality. Life is never the same after such an experience, both in body and soul. With humility, our logo seeks to symbolize a life rebuilt and sublimated after such a devastating illness.